Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 3.986


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
Elk1 13712 ELK1, member of ETS oncogene family
Elk4 13714 ELK4, member of ETS oncogene family
Gabpa 14390 GA repeat binding protein, alpha
Gabpb1 14391 GA repeat binding protein, beta 1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gabpachr16_+_848351310.651.5e-23Click!
Gabpb1chr2_-_1265011730.656.9e-23Click!
Elk4chr1_+_1339041620.073.8e-01Click!
Elk1chrX_-_20527674-0.055.3e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_117229719 41.801 NM_134010
 Nup107
nucleoporin 107
chr15_-_102181072 37.309 NM_153416
 Aaas
achalasia, adrenocortical insufficiency, alacrimia
chr19_+_6085096 36.407 NM_026410
 Cdca5
cell division cycle associated 5
chr16_-_18812064 35.458 NM_009862
 Cdc45
cell division cycle 45 homolog (S. cerevisiae)
chr9_-_57492978 32.922 NM_007783
 Csk
c-src tyrosine kinase
chr8_+_113580224 32.904 NM_028274
 Exosc6
exosome component 6
chr4_+_108520389 30.223 NM_029571
 Kti12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr11_-_94515034 29.335 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr19_+_38129500 29.205 NM_028293
NM_001164362
NM_028760
 Cep55


centrosomal protein 55


chr11_-_94515067 28.654 NM_177752
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr7_-_134185928 28.461 NM_145588
 Kif22
kinesin family member 22
chr3_-_129534201 28.444 NM_026578
 Gar1
GAR1 ribonucleoprotein homolog (yeast)
chr7_-_134185894 28.302 Kif22
kinesin family member 22
chr11_-_70051361 27.584 NM_001177601
NM_001177603
NM_001177606
NM_001177607
NM_026757
NM_145758
 0610010K14Rik





RIKEN cDNA 0610010K14 gene





chr11_-_70051346 27.551 0610010K14Rik
RIKEN cDNA 0610010K14 gene
chr4_+_44313764 26.423 NM_010790
 Melk
maternal embryonic leucine zipper kinase
chr3_+_137806411 26.411 NM_175389
 Rg9mtd2
RNA (guanine-9-) methyltransferase domain containing 2
chr3_+_87734217 26.375 NM_177663
 Isg20l2
interferon stimulated exonuclease gene 20-like 2
chr4_+_44313865 26.360 Melk
maternal embryonic leucine zipper kinase
chr2_+_5766079 25.764 NM_016918
 Nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 215 entries
Enrichment   P-value GO Accession GO Term
3.85 1.77e-05 GO:0000387 spliceosomal snRNP assembly
3.14 2.76e-09 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
3.14 2.76e-09 GO:0000398 nuclear mRNA splicing, via spliceosome
3.09 5.22e-09 GO:0000375 RNA splicing, via transesterification reactions
3.04 5.77e-09 GO:0071826 ribonucleoprotein complex subunit organization
2.97 9.13e-08 GO:0022618 ribonucleoprotein complex assembly
2.97 1.64e-04 GO:0006368 transcription elongation from RNA polymerase II promoter
2.94 1.51e-35 GO:0008380 RNA splicing
2.94 5.53e-11 GO:0006364 rRNA processing
2.92 8.41e-04 GO:0000956 nuclear-transcribed mRNA catabolic process
2.91 3.38e-23 GO:0022613 ribonucleoprotein complex biogenesis
2.90 2.41e-15 GO:0042254 ribosome biogenesis
2.90 1.70e-04 GO:0006354 transcription elongation, DNA-dependent
2.85 6.19e-23 GO:0071843 cellular component biogenesis at cellular level
2.85 2.90e-10 GO:0016072 rRNA metabolic process
2.85 8.30e-07 GO:0016573 histone acetylation
2.81 3.67e-02 GO:0008156 negative regulation of DNA replication
2.80 7.24e-03 GO:0043966 histone H3 acetylation
2.79 3.15e-32 GO:0006397 mRNA processing
2.79 1.44e-03 GO:0007249 I-kappaB kinase/NF-kappaB cascade

Gene overrepresentation in compartment category:

Showing 1 to 20 of 66 entries
Enrichment   P-value GO Accession GO Term
5.47 2.25e-02 GO:0030686 90S preribosome
4.10 1.32e-06 GO:0005689 U12-type spliceosomal complex
3.91 1.21e-02 GO:0030684 preribosome
3.80 6.05e-05 GO:0030532 small nuclear ribonucleoprotein complex
3.79 4.78e-02 GO:0005852 eukaryotic translation initiation factor 3 complex
3.48 2.00e-03 GO:0015030 Cajal body
3.45 1.16e-02 GO:0000784 nuclear chromosome, telomeric region
3.45 1.16e-02 GO:0005839 proteasome core complex
3.42 1.50e-15 GO:0071013 catalytic step 2 spliceosome
3.42 1.23e-03 GO:0044452 nucleolar part
3.30 1.29e-24 GO:0005681 spliceosomal complex
3.22 9.88e-05 GO:0022627 cytosolic small ribosomal subunit
3.02 8.19e-06 GO:0022626 cytosolic ribosome
2.93 1.67e-02 GO:0000781 chromosome, telomeric region
2.87 1.81e-06 GO:0000502 proteasome complex
2.82 1.07e-06 GO:0000123 histone acetyltransferase complex
2.79 7.54e-05 GO:0015935 small ribosomal subunit
2.78 2.58e-05 GO:0016607 nuclear speck
2.71 2.37e-14 GO:0016604 nuclear body
2.59 1.12e-44 GO:0030529 ribonucleoprotein complex

Gene overrepresentation in function category:

Showing 1 to 20 of 65 entries
Enrichment   P-value GO Accession GO Term
4.78 4.47e-02 GO:0070577 histone acetyl-lysine binding
3.38 1.14e-02 GO:0004298 threonine-type endopeptidase activity
3.38 1.14e-02 GO:0070003 threonine-type peptidase activity
3.23 2.32e-02 GO:0000049 tRNA binding
2.93 2.71e-02 GO:0003678 DNA helicase activity
2.73 1.95e-07 GO:0008026 ATP-dependent helicase activity
2.73 1.95e-07 GO:0070035 purine NTP-dependent helicase activity
2.73 1.01e-03 GO:0004812 aminoacyl-tRNA ligase activity
2.73 1.01e-03 GO:0016875 ligase activity, forming carbon-oxygen bonds
2.73 1.01e-03 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
2.67 8.26e-03 GO:0003684 damaged DNA binding
2.58 1.39e-03 GO:0004527 exonuclease activity
2.50 1.13e-03 GO:0003743 translation initiation factor activity
2.43 5.84e-08 GO:0003735 structural constituent of ribosome
2.41 8.06e-06 GO:0008135 translation factor activity, nucleic acid binding
2.31 1.68e-07 GO:0004386 helicase activity
2.28 4.04e-45 GO:0003723 RNA binding
2.17 2.70e-07 GO:0008168 methyltransferase activity
2.16 1.21e-02 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
2.12 9.00e-07 GO:0016741 transferase activity, transferring one-carbon groups